Physical Effects Research Articles

Cell Migration Chip (3DCM-chip): a New Tool Toward the Modelling of 3D Cellular Complex Systems.

3D hydrogel-based cell cultures provide models for studying cell behavior and can efficiently replicate the physiologic environment. Hydrogels can be tailored to mimic mechanical and biochemical properties of specific tissues and allow to produce gel-in-gel models. In this system, microspheres encapsulating cells are embedded in an outer hydrogel matrix, where cells are able to migrate. To enhance the efficiency of such studies, we design a lab-on-a-chip named 3D Cell Migration-chip (3DCM-chip) that offers substantial advantages over traditional methods. 3DCM-chip facilitates the analysis of biochemical and physical stimuli effects on cell migration/invasion in different cell types, including stem, normal and tumor cells. 3DCM-chip provides a smart platform for developing more complex cell co-cultures systems. Herein we investigate the impact of human fibroblasts on MDA-MB 231 breast cancer cells invasiveness. Moreover, how the presence of different cellular lines, including mesenchymal stem cells (hMSCs), normal human dermal fibroblasts (NHDFs), and human umbilical vein endothelial cells (HUVECs), affects the invasive behavior of cancer cells is investigated using 3DCM-chip and producing predictive tumoroid models with a more complex network of interactions between cells and microenvironment. 3DCM-chip moves us closer to creating in vitro systems that can potentially replicate key aspects of the physiological tumor microenvironment. This article is protected by copyright. All rights reserved.

ARTIFICIAL INTELLIGENT SYSTEM FOR AUTOMATIC DEPRESSION LEVEL ANALYSIS THROUGH VISUAL AND VOCAL EXPRESSIONS

Depression is a major mental health disease of human which is rapidly affecting lives worldwide. Early detection and intervention are crucial for effective treatment and management. Depression is regularly identified with thoughts of suicide. Significant depression can bring about a determination of social and physical side effects. It could remember changes in rest, craving, vitality level, concentration, day by day conduct or confidence. In recent years, deep-learned applications concentrated on neural networks have shown superior performance at hand-crafted apps in various areas. This system presents an innovative artificial intelligence (AI) system designed for automatic depression level analysis by analyzing visual and vocal expressions. Leveraging advances in computer vision and natural language processing, the proposed system extracts relevant features from facial expressions and speech patterns to assess depression severity levels accurately. Deep-learned apps that settle the above issues that may precisely assess the degree of voice and face depression. In the proposed method, Convolutionary Neural Networks (CNN) is developed for learning deep-learned features and descriptive raw waveforms for visual expressions. Second. Keywords: Artificial Intelligence, Depression, Vocal, Facial Expressions, Deep Learning

Quantum electrodynamics mediated by a photon with continuous spin

In recent work with Zhou, we studied classical interactions of matter with a “continuous spin” field, whose excitations have zero mass but nonzero spin Casimir (spin scale) ρ. We reported evidence that such theories are a calculable infrared deformation of familiar massless theories including electromagnetism. Building on the aforementioned work, this paper presents rules for computing scattering amplitudes involving charged scalar matter and continuous spin photons with nonzero spin scale. As a concrete example, we compute the pair annihilation and Compton scattering amplitudes in this theory and comment on their physical properties, including unitarity and scaling behavior at small and large ρ. Like the classical physics and soft factors studied in prior work, these amplitudes exhibit “helicity correspondence,” recovering familiar amplitudes at energy scales ≫ρ, but with calculable deviations that could be experimentally tested. These results bolster the conjecture that continuous spin particles with a very small ρ could mediate long-range forces in nature (e.g., the photon could be a continuous spin particle), and extend the range of physical effects that could be used to test this hypothesis. Published by the American Physical Society 2024

Childhood cancer models of survivorship care: a scoping review of elements of care and reported outcomes

Abstract Purpose This study aimed to systematically map elements of care and respective outcomes described in the literature for different models of post-treatment care for survivors of childhood cancer. Methods MEDLINE, CINAHL, and Embase were searched with combinations of free text terms, synonyms, and MeSH terms using Boolean operators and are current to January 2024. We included studies that described post-treatment cancer survivorship models of care and reported patient or service level elements of care or outcomes, which we mapped to the Quality of Cancer Survivorship Care Framework domains. Results Thirty-eight studies with diverse designs were included representing 6101 childhood cancer survivors (or their parent/caregiver) and 14 healthcare professionals. A diverse range of models of care were reported, including paediatric oncologist-led long-term follow-up, multi-disciplinary survivorship clinics, shared-care, and primary care-led follow-up. Elements of care at the individual level most commonly included surveillance for cancer recurrence as well as assessment of physical and psychological effects. At the service level, satisfaction with care was frequently reported but few studies reported how treatment-related-late effects were managed. The evidence does not support one model of care over another. Conclusions Gaps in evidence exist regarding distal outcomes such as costs, health care utilization, and mortality, as well as understanding outcomes of managing chronic disease and physical or psychological effects. The findings synthesized in this review provide a valuable reference point for future service planning and evaluation. Implications for Cancer Survivors Decades of research highlight the importance of survivorship care for childhood cancer survivors who are at risk of serious treatment-related late effects. This review emphasizes there is no single, ‘one-size fits all’ approach for delivering such care to this vulnerable population.

Spousal bereavement and four-year trajectories of medication use: A nationwide register-based study in Swedish older adults.

Medication use around widowhood has been poorly described for most medication classes. Medication use patterns can reflect health consequences of spousal loss, as previously shown for psychotropic drugs. We used data from nationwide health registers (2008-2020) to describe the patterns of use of dispensed medications in all widowed Swedes aged ≥65 years followed between 2 years before and 2 years after spousal death. All prescription drugs used by at least 5% of the cohort were considered according to their therapeutic subgroups (Anatomical Therapeutic Chemical [ATC] classification system 2nd level). We used group-based trajectory models to cluster widowed individuals into up to 4 distinct longitudinal patterns of monthly medication use. We ranked the therapeutic subgroups with similar patterns according to their plausibility to reflect potential health effects of spousal loss, compared to those of psycholeptics (mainly anxiolytics, hypnotics) and psychoanaleptics (mainly antidepressants) as the references. From 212,111 widowed adults included (68% female and 70% aged ≥75 years), we observed a significant increasing trend in medication use, especially after spousal death, for 21 out of the 39 different therapeutic subgroups that were used by at least 5% (most represented pharmacological groups: cardiovascular system, nervous system, and alimentary tract and metabolism). This increasing trend often concerned only a small proportion of individuals, with varying magnitude and speed of change in medication use across therapeutic subgroups. The patterns of use of antiepileptics, laxatives, skin emollients/protectives, analgesics, and drugs for anemia, constipation, or peptic ulcers, were the closest to those of references, displaying the largest changes in use, and were therefore ranked as the most likely to reflect health effects of spousal loss. Our results confirmed the increase in psychotropic medications' use in widowed older adults and identified several potential physical health effects of spousal loss that warrant further research.

Quality of Life of Dialysis Patients: Exploring the Influence of Membrane Hemocompatibility and Dialysis Practices on Psychosocial and Physical Symptoms

Hemodialysis (HD) is a life-sustaining membrane-based therapy that is essential for managing kidney failure. However, it can have significant physical and psychological effects on patients due to chronic or acute consequences related to membrane bioincompatibility. End-stage renal disease (ESRD) patients on hemodialysis have a high incidence of psychiatric illness, particularly depression and anxiety disorders, and poor quality of life has been observed. Dialysis can also lead to physical symptoms of its own, such as fatigue, loss of appetite, anemia, low blood pressure, and fluid overload, in addition to the symptoms associated with kidney failure. Therefore, this critical review aims to comprehensively understand the impact of dialysis membrane bioincompatibility and the use of varying molecular weight cut-off membranes on the physical and psychological symptoms experienced by dialysis patients. We analyzed the latest research on the correlation between major inflammatory biomarkers released in patients’ blood due to membrane incompatibility, as well as the critical influence of low levels of hemoglobin and vital proteins such as human serum albumin due to the use of high-cut-off membranes and correlated these factors with the physical and psychological symptoms experienced by dialysis patients. Furthermore, our study aims to provide valuable insights into the impact of dialysis on critical symptoms, higher hospitalization rates, and the quality of life of First Nations, as well as child and youth dialysis patients, in addition to diabetic dialysis patients. Our goal is to identify potential interventions aiming to optimize the dialysis membrane and minimize its negative effects on patients, ultimately improving their well-being and long-term outcomes.

Investigation of Classroom Teachers' Technostress Levels in Terms of ICT Competence Perceptions and Various Variables

Technostress refers to the negative psychological and physical effects of technology use (Brod, 1984; Shu, Tu, & Wang ,2011). The reasons for this include factors such as information overload and inability to cope with the pressure to stay up to date with technology. Undoubtedly, there is a strong relationship between technostress and technology use (Brod, 1984). Today, technostress has become a common problem among teachers (Madigan & Kim, 2021). This study aims to reveal the relationship between the levels of technostress that classroom teachers may have experienced and their perceptions of competence towards Information Communication Technologies (ICT). In addition, teachers' technostress levels and ICT efficacy perceptions were examined in terms of various descriptive variables. The study was conducted with the relational survey model, one of the quantitative research methods, and two scales and various descriptive questions were used. In the study, independent sample t-test, Mann-Whitney U test and one sample ANOVA were used to determine the difference between multi-group variables. Bivariate Pearson correlation analysis was applied to test the relationship. The results of the analysis showed that there was a statistically significant relationship between teachers' technostress levels and their perceptions of ICT efficacy (r= 0.343; p

Degradation exposure scenario in the Brazilian Amazon: Edge effect on hyperdominant C-cycle tree species

The Amazon basin strongly influences the global carbon cycle, storing billions of tonnes of carbon in a relatively small number of ‘hyperdominant’ tree species. However, the Amazon carbon stock is threatened by land-use change. In the remaining forest patches, trees close to the forest border bear various physical and biotic edge effects that alter plant growth and survival. To assess how edge effects influence tree mortality and carbon storage, we investigated the occurrence of hyperdominant tree species in the Brazilian Amazon between 1988 and 2021. Evaluating tree records from a network of permanent plots and herbarium collections, we found that 22 % of tree occurrence records were in deforested areas, 35% within 1 km of the forest edge, and 43 % in continuous forest. At the local scale in Central Amazonia, tree monitoring data over 30 years revealed that forest fragments hyperdominant trees had twice the mortality rate of continuous forest ones due to edge effects during the 15 years following edge establishment. Although trees in fragments had higher initial growth, this pattern declined over the years and eventually resulted in significant carbon loss, mainly from tree mortality. Edge effects have led to annual declines in the biomass of forest remnants, suggesting that hyperdominant species are also susceptible to disturbances that lead to degradation and forest losses. Conservation of the Amazon forests requires an approach that considers the effects of local disturbances on carbon stocks in the region.

[Effects of a Motivational Intervention on the Effectiveness and Sustainability of Sports and Exercise Therapy in Inpatient Psychiatric Care].

Reinforcement and sustainability of sports and exercise therapy in inpatient depression treatment. Randomized controlled study with 3 measurement times: t0 admission to the study, t1 after four weeks, t2 two months after discharge. 96 inpatients with depressive disorders (ICD-10 F32, F33) were randomly assigned to an intervention group (IG) or a control group (KG). In addition to sports and exercise therapy (KG), the IG received an educational and motivational session on the importance of sports and exercise, as well as a motivational final discussion. Endurance performance and physical fitness improved more significantly in the IG than in the CG over the 3 measurement times. The motivational final discussion was rated as more helpful. The intervention was well accepted by the patients and partially increased the effects of sports and exercise therapy. Not only psychological aspects of depression treatment were influenced, but also measurable physical effects. The practical and time-efficient motivational intervention in inpatient psychiatric care can complement sports and exercise therapy for depressive patients.

Understanding the Cascade: Removing GCM Biases Improves Dynamically Downscaled Climate Projections

AbstractPolarization surrounding bias correction (BC) in creating climate projections arises from its lack of physicality. Here, we perform and analyze 18 dynamical downscaling simulations (with and without BC) to better understand the physical impacts of BC, applied before downscaling, on regional climate output across the western United States. Without BC, downscaled precipitation is systematically and unrealistically wet biased compared to a hierarchy of observationally based datasets over the 1980–2014 period due to cascading mean‐state Global Climate Model (GCM) biases: (a) overly strong lower‐tropospheric lapse rates (5 K/km), (b) overly cold (2 K) tropospheric temperatures, and (c) anomalous mid‐tropospheric cyclonic vorticity advection. With BC, downscaled precipitation (snow) biases are virtually eliminated (halved). Identified GCM biases are common to the broader Coupled Model Intercomparison Project ensemble. Physical effects of BC on the quality of the regionalized projections, pending an evaluation of BC's distortion of the downscaled climate response, may motivate its broader application by dynamical downscalers.

Abstract PO3-28-01: More Than a Diagnosis: An Untold Story of Quality of Life

Abstract Background Advocates for Collaborative Education, a global coalition of patient, community, research, and policy advocates, initiated an anonymous, online survey to assess Quality of Life (QoL) impacts of cancer diagnosis and treatment to inform research, clinical care, and the broader cancer community. Identifying what matters most to individuals can potentially guide improvements in supportive care to effectively address QoL impacts. Methods A six-section, 93 question survey was co-created by patients, survivors, and advocates. Co-creation was instrumental in determining categories, specific questions, and measurement scales used to assess severity and impact of QoL challenges. Beyond demographic, treatment, and cancer diagnosis data, co-creation participants identified seventeen (17) treatment-related side effects. Survey questions asked about these side effects, their perceived severity, how well informed they felt about possibilities of experiencing these side effects, supportive care access, side effects of supportive care therapies, and personal preferences for receiving cancer-related information. Recruitment efforts for this online survey were conducted through advocacy groups and social media platforms. Results Across a wide range of demographic subsets, including age, race, stage of cancer, and treatment modalities, 334 respondents with a history of breast cancer reported a decline in QoL scores pre cancer vs post cancer according to the co-created measurement tool. Physical and emotional well-being emerged as top priorities for most respondents, 47.9% and 27.5% respectively. Of 17 listed side effects, respondents cited fatigue (49%), muscle/joint pain (36%), and emotional distress (35%) as primary concerns, with sexual dysfunction and cognitive impairment ranking prominently. Forty-six percent reported severe (frequent & highly disruptive) to very severe (constant & severely impacting quality of life) emotional distress, but only 55% of those felt informed or well informed about the possibility of emotional distress. Among respondents, only 41% received a plan to address emotional distress. Many felt unprepared for physical side effects as well. While 54% of individuals experienced diarrhea or fecal incontinence as a treatment side effect, 22% of affected individuals did not feel informed about the possibility of such side effects. Survey findings also highlight consequences of treatments to manage side effects. For example, 37% of respondents were prescribed treatment to address diarrhea and 100% of these patients reported additional side effects stemming from this supportive care including nausea, constipation, and fatigue. Detailed results for all categories as well as stratification by subsets of age, race, metastatic vs. early stage, treatment type, and others will be available for presentation and publication. Conclusion This study sheds light on an underexplored area of cancer research. Management of treatment side effects is integral to supportive care, yet supportive medications can introduce a cascade of their own side effects, exacerbating the overall burden on patients. Information and education are critical to bridge the gap. The collaboration with patients and survivors in developing this survey represents a pivotal step in determining areas that demand attention for improving QoL and offers valuable insights aimed at enhancing the well-being of individuals affected by cancer and additional research will pursue collaborative solutions. Demographic and High Level QoL Responses from MTAD (Breast) Detailed data on perceived severity, impact to QoL, perceived preparation for, and relevant supportive care is available for each side effect Citation Format: Stacey Tinianov, Kelly Shanahan, Catherine Thomsen, Ginny Mason, Laura Carfang, Joanne Mika Hayashi, Laurie Hutcheson. More Than a Diagnosis: An Untold Story of Quality of Life [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO3-28-01.

Concerns about fertility, social appearance, and relationships in young adults with polycystic ovary syndrome

ABSTRACT Background Polycystic Ovary Syndrome (PCOS), affecting 1–11% of reproductive-age women, is characterised by many symptoms that cause important concerns especially in young adults. Objective This study aimed to evaluate the concerns about fertility, social appearance, and relationships in young adults with PCOS. Methodology This descriptive study included 140 young female adults aged 18–26, who were diagnosed with PCOS, agreed to participate in the onlineresearch through social media between July and December 2022 in Turkey. Data were collected using the ’Participant Interview Form’ and the ”Social Appearance Anxiety Scale (SAAS). Results The mean age of the participants was 22.1 ± 2.1. As the most common symptoms, 78.6% experienced menstrual irregularities, 16.4% were overweight, 7.1% were obese, 67.1% had hirsutism and 65.7% had acne. Most of the participants expressed concerns about future infertility (72.9%), and worried about being unable to conceive due to PCOS in the future (sometimes = 61.4%). Over eighty percent of the participants expressed some level of dissatisfaction with their physical appearance. They commonly believe that their self-esteem, emotionalstate, social relationships and partner relationships could be negatively affected by PCOS. SAAS scores were significantly increased by low income, high BMI, hirsutism, dissatisfaction with physicalappearance, low self-esteem, emotional problems and concerns related to social and partner relationships (p < 0.05). Conclusion Young adults have common concerns about the potential negative impacts of PCOS on fertility, social appearance, and relationships. Health professionals should be aware of their counselling needs about the possible physical and psycho-social effects of PCOS and provide continuous care and support.

Recent Developments on the Effects of Micro- and Nano-Limestone on the Hydration Process, Products, and Kinetics of Cement.

Limestone is commonly used in cement concrete due to its unique nature and type. It has physical effects (nucleation effect and dilution effect) and chemical effects on the hydration process of cement. This paper reviews the effects of three representative limestone materials on the hydration process, hydration products, and hydration kinetics. In the hydration process, the reaction was delayed by limestone powder with a particle size larger than 20 μm and calcium carbonate whiskers due to their dilutive effect. On the other hand, limestone powder with a particle size smaller than 20 m and calcium carbonate nanoparticles facilitated the reaction through nucleation and chemical effects. Limestone has a similar effect on hydration products, promoting the production of C-S-H through nucleation. The mechanism of action for this nucleation effect depends on the differences in crystalline form and particle size of the three types of micro- and nano-calcium. Chemical effects impact the amount of AFt produced, with the generation of new products being the main reaction influenced by the limestone admixture.

Exploring the structure, characteristics, and thermal degradation of composites comprising thermoplastic polyolefin and graphene oxide under high-temperature dynamic shear conditions

Dynamic high-temperature shear aging tests were conducted on thermoplastic polyolefin (TPO)/graphene oxide (GO) composite materials using a Hakke torque rheometer. The study employed ATR-FTIR, DSC, SEM, oxygen performance testing, and TGA to analyze the structure, properties, thermal degradation behavior, kinetics, and mechanisms of TPO/GO composites. The results demonstrated that the high-temperature dynamic shear thermal oxidative aging of TPO/GO composite materials establishes a dual protective mechanism, incorporating physical (intercalation oxygen resistance) and chemical (inorganic oxygen resistance) effects. This can be attributed to the polar surface and honeycomb structure of GO, as well as the shear-induced more uniform physical distribution of GO within TPO. Consequently, TPO/GO composite materials exhibit significantly enhanced resistance to dynamic shear thermal oxidative aging compared to TPO alone.

Female Genital Mutilation practiced by Dawoodi Bohras of Pakistan

This paper examines the practice of female genital mutilation (FGM) among the Dawoodi Bohra community in Pakistan. FGM, a non-therapeutic alteration of the female genitalia, is examined through the lenses of religion, culture and health. The Dawoodi Bohra, predominantly based in Karachi, practice FGM as a religious and cultural rite, linking it to notions of purity and social acceptance. Despite global efforts to outlaw and eradicate FGM, it persists, underpinned by deeply held beliefs and the insular nature of the community. The physical and psychological effects of FGM are profound, leading to immediate and long-term complications such as severe pain, infection and psychological trauma. This paper discusses the impact of these practices on women’s health and rights, while critiquing the lack of an effective legal framework in Pakistan to combat FGM. In addressing this issue, the paper contributes to the broader discourse on gender-based violence and the rights of women and children in patriarchal societies.

Metaphorical Perceptions of Surgical Nurses Regarding Care for Earthquake Victims

BackgroundThe physical, psychological, and social effects of the earthquake affect a person's functionality directly. It challenges individuals because it is often traumatizing, intense fear is experienced, and it is unpredictable, uncontrollable, and destructive. Nurses are one of the professional groups that have important duties in social disasters, and they are constantly exposed to the details of the traumatic situation, sometimes physically and sometimes by listening. To understand the severity of the trauma caused by this exposure, it is important to understand the emotions and thoughts that nurses feel while caring for earthquake victims. AimsThis study was planned to reveal the perceptions of nurses, who were themselves earthquake victims, regarding caring for earthquake victims through metaphors.. MethodsThis study was conducted as a phenomenological study with a qualitative research approach, in a province affected by the earthquake, with 85 surgical clinic nurses who were also earthquake victims and cared for earthquake victims. ResultsThe metaphors produced were examined together with their reasons and grouped under 3 categories (positive, negative, both positive and negative). ConclusionsAs a result, when the metaphors used by earthquake victims are evaluated, the effects of nurses being earthquake victims themselves can be seen in the metaphors. It is revealed through metaphors that nurses' earthquake-related traumas are triggered while caring for earthquake victims.

From layer to building: multiscale modeling of thermo-optical properties in 3D-printed facades

The challenge of building sector decarbonization has driven an integral rethinking of the way we design and build facades. Recently, large scale 3D-printing has emerged as an alternative manufacturing technique for novel facade components aiming at high operational efficiency and low environmental impact. Focusing on translucent polymer 3DPFs, this study tackles the challenges of modeling thermal and optical effects in geometrically complex components where interactions across multiple domains and scales occur. In particular, we introduce a novel method for modeling the irregular thermo-optical properties of 3DPFs, capable of capturing relevant effects often out of the scope of traditional modeling approaches. Our model accounts for geometry-dependent physical effects ranging from millimeter-scale fabrication details that impact optical behavior to centimeter-scale geometric features influencing heat and radiation transfer, extending up to the meter-scale implications for the building application. By employing computational techniques such as ray-tracing, computational fluid dynamics, and finite element analysis, we establish a model that offers detailed thermal and optical analysis to support performance-driven design iterations. Finally, demonstrating this approach in an office building context, we show that 3DPFs can match the performance of double glazing with dynamic shading, providing effective solar and thermal management over the year. This is achieved in a single, mono-material component with no active control, suggesting 3DPFs are a promising direction for low-environmental impact facade design.

Quantifying the effect of X-ray scattering for data generation in real-time defect detection.

X-ray imaging is widely used for the non-destructive detection of defects in industrial products on a conveyor belt. In-line detection requires highly accurate, robust, and fast algorithms. Deep Convolutional Neural Networks (DCNNs) satisfy these requirements when a large amount of labeled data is available. To overcome the challenge of collecting these data, different methods of X-ray image generation are considered. Depending on the desired degree of similarity to real data, different physical effects should either be simulated or can be ignored. X-ray scattering is known to be computationally expensive to simulate, and this effect can greatly affect the accuracy of a generated X-ray image. We aim to quantitatively evaluate the effect of scattering on defect detection. Monte-Carlo simulation is used to generate X-ray scattering distribution. DCNNs are trained on the data with and without scattering and applied to the same test datasets. Probability of Detection (POD) curves are computed to compare their performance, characterized by the size of the smallest detectable defect. We apply the methodology to a model problem of defect detection in cylinders. When trained on data without scattering, DCNNs reliably detect defects larger than 1.3mm, and using data with scattering improves performance by less than 5%. If the analysis is performed on the cases with large scattering-to-primary ratio (1<SPR<5), the difference in performance could reach 15% (approx. 0.4mm). Excluding the scattering signal from the training data has the largest effect on the smallest detectable defects, and the difference decreases for larger defects. The scattering-to-primary ratio has a significant effect on detection performance and the required accuracy of data generation.

Content analysis of Reddit posts about coadministration of selective serotonin reuptake inhibitors and psilocybin mushrooms.

Treatments with the serotonergic psychedelic psilocybin are being investigated for multiple neuropsychiatric disorders. Because many patients with these disorders use selective serotonin reuptake inhibitors (SSRIs), understanding interactions between psilocybin and SSRIs is critical for evaluating the safety, efficacy, and scalability of psilocybin-based treatments. Current knowledge about these interactions is limited, as most clinical psilocybin research has prohibited concomittant SSRI use. We aimed to explore potential interactions between psilocybin and SSRIs by characterizing peoples' real-world experiences using psilocybin mushrooms and SSRIs together. We conducted a systematic search of Reddit for posts describing psilocybin mushroom and SSRI coadministration. We identified 443 eligible posts and applied qualitative content analysis to each. 8% of posts reported negative physical or psychological effects resulting from coadministration. These included 13 reports that may reflect serotonin toxicity, and 1 concerning for a psychotic/manic episode. 54% of posts described reduced intensity of the acute psilocybin experience, but 39% reported unchanged intensity with SSRI coadministration. Psilocybin's interactions with SSRIs are likely complex and may depend on multiple factors. Prospective studies are needed to evaluate whether psilocybin treatments are reliably safe and effective in the setting of SSRI use.

강간 피해자의 원하지 않은 임신도 상해인가?

Recently, in the Supreme Court of Korea, there has been controversy over whether the victim's pregnancy is bodily injury in the case where the defendant, a stepfather, sexually assaulted an 11-year-old stepdaughter to become pregnant, and in the case where the defendant sexually assaulted a friend of his wife who was asleep under the influence of alcohol at his home. The prosecutor regarded the undesired pregnancy as bodily injury and prosecuted the defendant for aggravated-rape and aggravated-quasi-rape in these cases, but the Supreme Court of Korea admitted only rape and quasi-rape because the undesired pregnancy did not constitute bodily injury. Some scholars argue that pregnancy due to rape should be considered bodily injury, but discussions in Korea are still insufficient. Even in the context of US precedents, the question of whether a rape victim's pregnancy constitutes substantial bodily injury has arisen in numerous statutory rape cases, including a case in which a stepfather sexually assaulted a 13-year-old stepdaughter for months, leading to pregnancy, and then aborted. The pregnancy of a rape victim negatively affects the victim's physical and mental aspects. Therefore, it is argued that the physical and mental effects of pregnancy are the same as substantial bodily injury, and that the pregnancy of rape victims should be recognized as a factor that increases the punishment of rape. However, US precedents and legislation have different positions on whether to view physical changes caused by the pregnancy of rape victims as elements of aggravated punishment. Korean courts have not yet recognized the unwanted pregnancy of rape victims as bodily injury. However, in the United States, legal precedents sometimes consider the pregnancy of rape victims as bodily injury, and individual state legislations also recognize this. This paper compared and examined related precedents and legislation in Korea and the United States, and studied the question of whether to view the unwanted pregnancy of rape victims as bodily injury. In conclusion, the author of this paper argues in favor of interpretive and legislative theories that advocate for viewing the pregnancy of rape victims as bodily injury.